Dublin is unique in the fact that it offers proximity to several major state and national highways.

Interstate 16 cuts directly through Laurens County and serves as a major artery for the state of Georgia, connecting interstates 95 and 75. Dublin, with its central location on I-16, presents the ability to quickly access I-95, the foremost interstate highway on the East Coast of the U.S. Additionally, Interstate 75, which runs from the southern tip of Florida to the northern tip of Michigan, can be accessed within an hour from Dublin-Laurens County.

Because of its location on U.S Route 441, Dublin is connected to key major urban areas such as Miami, Orlando, Gainesville, Athens, and Knoxville. U.S. Hwy 441 runs for 939 miles from Miami to Rocky Top in Northeastern Tennessee.

Dublin also has a location on U.S. Route 80. Route 80 begins in Dallas, Texas, and runs east until it meets the ocean in Tybee Island, Georgia. Highway 80 serves as a major route of east/west travel for Georgia, Alabama, Mississippi, Louisiana, and Texas.  Georgia State Route 257 runs from Cordele to Dublin, and U.S. Route 319, which stretches from the panhandle of Florida, to Wadley, Georgia, runs through Dublin.

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